Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein.

نویسندگان

  • B J Terry
  • W C Liu
  • C W Cianci
  • E Proszynski
  • P Fernandes
  • K Bush
  • E Meyers
چکیده

Herpesviruses are a commonvirus infecting man. Twodrugs have shown clinical efficacyin the treatment of herpesvirus infections, acyclovir and ganciclovir. Acyclovir has excellent antiviral activity against herpes simplex types 1 and 21}; ganciclovir is potent against human cytomegalovirus2). Both drugs are nucleoside analogs and are metabolized to their respective triphosphates which then block viral DNA replication by inhibiting the viral DNA polymerase3'4).

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 45 2  شماره 

صفحات  -

تاریخ انتشار 1992